From the last blog we presented impaired methylation and the connection to autism. This week, we look at a specific case where a subject, named Chris, was given treatment through nutrition and supplements.
Treatment: Elimination diet 6 weeks followed by no gluten or cow dairy.
chewable muti-vitamins (organic)
Probiotics c FOS
B12/5mthf, B6, mg glycinate, Nac
Phospho serine at Hs
The symptoms resolved! Although a few minor issues with dyslexia continued, Chris integrated back into school after his mom took him out of school and home schooled him for a year until she could control his diet. Methyl-folate and methyl-B12 were added this past year which helps energy and support detoxification in Phase II of the liver function.
INTERVENTION 1: Supplementation with folinic acid and betaine
Although supplementation was effective in normalizing the methionine cycle metabolites to the concentrations in the control subjects, the intervention significantly improved but did not normalize tGSH or GSSG concentrations or tGSH:GSSG
INTERVENTION 2: Supplementation with folinic acid and betaine and Methyl vitamin B12
The addition of injectible methylcobalamin (intervention 2) did not alter the mean concentrations of methionine, SAM, SAH, or homocysteine beyond the alterations induced by the intervention with folinic acid and betaine. However, relative to intervention 1, the addition of injectible methylcobalamin further decreased the concentrations of adenosine and GSSG and further increased the concentrations of methionine, cysteine, and tGSH and SAM:SAH and tGSH:GSSG.