Methylation and Nutrition

We’ve been on a long series about Methylation and how an individual’s nutrition can affect the outcome of their health. Here’s a quick review of MTHFR:

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Once the MTHFR tests shows (+) variants exist, what else can the health provider do to effectively treat the patient?

MTHFR-solutions-baucom-institute

So, what are you doing as a patient to take control of your health in relation to genome testing and restorative care with a physician that understands the impact of these aspects?

As a medical practitioner, are you having your patients tested for this all important genome so that they can be more proactive with their health and prevent disease?

Autism and Impaired Methylation

  • epigenetics-autism-methylation-baucom-instituteAn increased vulnerability to oxidative stress and a decreased capacity for methylation may contribute to the development and clinical manifestation of autism.

  • Children with autism had significantly lower baseline plasma concentrations of methionine, SAM, homocysteine, cystathionine, cysteine, and total glutathione and significantly higher concentrations of SAH, adenosine, and oxidized glutathione.

  • Consistent with impaired capacity for methylation (significantly lower ratio of SAM to SAH) and increased oxidative stress (significantly lower redox ratio of reduced glutathione to oxidized glutathione).

Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with Autism 1 From the Department of Pediatrics, University of Arkansas for Medical Sciences, and the Arkansas Children‘s Hospital Research Institute, Little Rock, AR (SJJ, SM, and SJ); Niagara Falls, NY (PC); Colden, NY (LJ); Gaylor and Associates, LLC, Eureka Springs, AR (DWG); and Edison, NJ (JAN)2 Rep

PMhx – case:autism-methylation-baucom-institute

  • 6 years old
  • HM hx of severe anxiety,
  • unable to perform in class,
  • crying,
  • restless,
  • insomnia,
  • ADD,
  • dyslexia
  • small bumps on cheeks and upper arms mom describes as acne..

The mother of the child took him to the doctor to medicate him for anxiety and for a referral to a special education program. The mother was considering home schooling due to the severity of the child’s anxiety. This testing was done in addition:

  • Labs:  HLA Dq2/ Hla Dq8 negative

  • Food allergy test + gluten, wheat, dairy, honey, yeast, and some other minor antibodies (leaky gut).

  • MTHFR: c677T+/A1298C+

Stay tuned for the results on our next blog.

Methylation

Methylation can turn genes on or off.

Some nutrients affect the methylation process quite dramatically. Methylating factors like B12, B6, MD, Zinc monitor specific methylation reactions.

Methylation_DNA_Baucom_InstituteMTHFR

What is MTHFR?

  • Methylenehydrofolatereductase is an enzyme responsible for converting 5, 10- methylenetetrahydrofolate to the product: 5-methytetrahydrofolate (5-MTHF)
  • Certain mutations in the gene coding for MTHFR produce an enzyme that has reduced activity
  • Reduced activity can lead to elevated levels of homocysteine especially when folate levels are low
  • MTHRF genotyping can provide information about potential causes of elevated homocysteine and how to address it
  • 5-methyltetrahydrofolate is involved in the metabolism of folate and homocysteine
  • The product of the reaction catalyzed by MTHFR converts homocysteine (a potentially toxic amino acid) to methionine (a useful and necessary amino acid)