Autism and Impaired Methylation: PMhx Case – Chris

From the last blog we presented impaired methylation and the connection to autism. This week, we look at a specific case where a subject, named Chris, was given treatment through nutrition and supplements.

  • Treatment: Elimination diet 6 weeks followed by no gluten or cow dairy.autism-baucom-institute

  • EPA/DHA liquid

  • chewable muti-vitamins (organic)

  • Probiotics c FOS

  • B12/5mthf, B6, mg glycinate, Nac

  • Phospho serine at  Hs

The symptoms resolved! Although a few minor issues with dyslexia continued, Chris integrated back into school after his mom took him out of school and home schooled him for a year until she could control his diet.  Methyl-folate and methyl-B12 were added this past year which helps energy and support detoxification in Phase II of the liver function.

nutrition-autism-baucom-instituteINTERVENTION 1: Supplementation with folinic acid and betaine

Although supplementation was effective in normalizing the methionine cycle metabolites to the concentrations in the control subjects, the intervention significantly improved but did not normalize tGSH or GSSG concentrations or tGSH:GSSG

INTERVENTION 2: Supplementation with folinic acid and betaine and Methyl vitamin B12

The addition of injectible methylcobalamin (intervention 2) did not alter the mean concentrations of methionine, SAM, SAH, or homocysteine beyond the alterations induced by the intervention with folinic acid and betaine. However, relative to intervention 1, the addition of injectible methylcobalamin further decreased the concentrations of adenosine and GSSG and further increased the concentrations of methionine, cysteine, and tGSH and SAM:SAH and tGSH:GSSG.

Autism and Impaired Methylation

  • epigenetics-autism-methylation-baucom-instituteAn increased vulnerability to oxidative stress and a decreased capacity for methylation may contribute to the development and clinical manifestation of autism.

  • Children with autism had significantly lower baseline plasma concentrations of methionine, SAM, homocysteine, cystathionine, cysteine, and total glutathione and significantly higher concentrations of SAH, adenosine, and oxidized glutathione.

  • Consistent with impaired capacity for methylation (significantly lower ratio of SAM to SAH) and increased oxidative stress (significantly lower redox ratio of reduced glutathione to oxidized glutathione).

Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with Autism 1 From the Department of Pediatrics, University of Arkansas for Medical Sciences, and the Arkansas Children‘s Hospital Research Institute, Little Rock, AR (SJJ, SM, and SJ); Niagara Falls, NY (PC); Colden, NY (LJ); Gaylor and Associates, LLC, Eureka Springs, AR (DWG); and Edison, NJ (JAN)2 Rep

PMhx – case:autism-methylation-baucom-institute

  • 6 years old
  • HM hx of severe anxiety,
  • unable to perform in class,
  • crying,
  • restless,
  • insomnia,
  • ADD,
  • dyslexia
  • small bumps on cheeks and upper arms mom describes as acne..

The mother of the child took him to the doctor to medicate him for anxiety and for a referral to a special education program. The mother was considering home schooling due to the severity of the child’s anxiety. This testing was done in addition:

  • Labs:  HLA Dq2/ Hla Dq8 negative

  • Food allergy test + gluten, wheat, dairy, honey, yeast, and some other minor antibodies (leaky gut).

  • MTHFR: c677T+/A1298C+

Stay tuned for the results on our next blog.