Methionine Synthase Mutations

  • 250px-PBB_Protein_MTR_image_Baucom_InstituteMutations in the MTR gene have been identified as the underlying cause of methylcobalamine deficiency.

  • This may lead to megaloblastic anemia as seen in elevated MCV in the patients CBC.

  • Patients may actually have high levels of B12 in the serum as the Cobalamine is not converting to Methylcobalamine.

  • May compound mutations in MTHFR

Mega Dosages of Me-B12B12_b-s

  • Supplementation with megadoses of MeB12 has been advocated to protect the cognitive function of patients suffering from:

  • Chronic Fatigue

  • Stroke

  • Depression

  • Alzheimer’s disease Neurological diseases

What Does Gluten Do?

Rose Family Fall 2013 074Maddy’s story begins like so many others – born into a middle class family in the midwest, she has had the privileges of most teenagers her age and is now a freshman Criminal Justice major at Olivet Nazarene University in Bourbonnais, Illinois.

Maddy has found that eating is a rather difficult thing, especially at college, even though they have a gluten-free menu, because of all the temptations on the regular menu. She has a gluten intolerance, on the extreme end. It makes it hard to take care of herself away from home, yet she’s working hard to do it, realizing that eating gluten is just not worth the pain.

Maddy says, “First off, you can tell as you are eating it you start to feel full but you aren’t sure if you are bloated or if you are actually getting full. After you’ve eaten, about only 30 minutes later, you start to get indigestion. You get really bad issues that come with extreme gastrointestinal stress, extreme nausea, heavy fatigue, you become moody and irritable and it can even result in vomiting. You also have energy depletion and headaches that include throbbing, making it hard to focus. Speaking of focus, your attention span is decreased, making it hard to work, study, pay attention in class, and go through daily activities that would normally not be an issue for you. You also feel heavy, muggy, miserable, and all around sickly. I also get hot and cold flashes sometimes – that’s when I know it’s really severe. It wasn’t until I talked to Dr. Baucom about my symptoms that I realized why I was having trouble every time I ate. She had me read various articles on gluten, making me realize I was on the extreme end of this issue.”

What is gluten? It is a protein that has been engineered as a component of wheat that provides the elastic qualities for baked goods. But the protein is also difficult to digest. And even a healthy intestine does not completely break gluten down. For those with celiac disease, the undigested gluten essentially causes the body’s immune system to lash out at itself, leading to malabsorption, bloating and diarrhea — the classic gastrointestinal symptoms — but also, at times, joint pain, skin rashes, etc.

Joseph A. Murray, a gastroenterologist at the Mayo Clinic in Rochester, Minnesota says of gluten-intolerance, “It truly has become more common.” Comparing blood samples from the 1950s to the 1990s, Murray found that young people today are nearly five times as likely to have celiac disease, for reasons he and others researchers cannot explain. And it’s on the rise not only in the U.S. but also in other places where the disease was once considered rare, like Mexico and India. “We don’t know where it’s going to end,” Murray says.

Mark Hyman, M.D. practicing physician and founder of The UltraWellness Center is a pioneer in functional medicine. He’s done some extensive study on the effects of gluten. He says that a review paper in The New England Journal of Medicine listed 55 “diseases” that can be caused by eating gluten. (iv) These include osteoporosis, irritable bowel disease, inflammatory bowel disease, anemia, cancer, fatigue, canker sores, (v) and rheumatoid arthritis, lupus, multiple sclerosis, and almost all other autoimmune diseases. Gluten is also linked to many psychiatric (vi) and neurological diseases, including anxiety, depression, (vii) schizophrenia, (viii) dementia, (ix) migraines, epilepsy, and neuropathy (nerve damage). (x) It has also been linked to autism.(ix)

Gluten sensitivity is actually an autoimmune disease that creates inflammation throughoutgluten-warning-baucom-institute the body, with wide-ranging effects across all organ systems including your brain, heart, joints, digestive tract, and more. It can be the single cause behind many different “diseases.” To correct these diseases, you need to treat the cause–which is often gluten sensitivity–not just the symptoms.

How can you know if you are gluten-intolerant? Try going off food that causes the symptoms – breads, pastas, sauces made with flour, chips, french fries, chocolate, anything with wheat or barley in it, etc. Even body and hair care products can have gluten and can be absorbed through the skin. See how you feel. If you have less symptoms like intestinal distress, bloating, etc. you know that gluten was at least a culprit. Most importantly seek a medical professional educated in restorative medicine or naturopathic education. Unfortunately, most MD’s are not aware nor educated on the effects of gluten, although society’s awareness is pushing the medical community to become more aware.

How do you relate to Maddy’s story? What symptoms cause you to think you may be gluten intolerant?

Intestinal Health – the Four “R” Program: Part IV – Obesity

mid section view of a man sitting on a bench in a park

In Part I of our four-part series, we looked at the gut and how bacteria plays a part in a good way and a bad one as well as the treatment for it – the Four R Program - four steps to creating a healthy gut:  Remove, Replace, Reinoculate, Repair.

In Part II, we looked at bacteria specifically in relation to our gut health and what it does to create havoc in our system, not just our gut.

In Part III, we dealt with yeast and fungi in relation to the gut and the treatment options that are available to deal with these two gut busters.

In Part IV, we’ll look at how obesity plays a part in overall gut health.

Why?

Research has found that obesity has a microbial component that alters caloric yield from ingested food. Altering the gut microbiota may also improve insulin sensitivity and glucose intolerance.

What causes this?

Bacteria (Firmicutes and Bacteroidetes classes – Clostridiasp., Streptomyces sp., Lactobacillus sp., Mycolplasma sp., Bacillus sp., Bacteroides sp., and Prevotella sp.) known to increase caloric extraction from food are present. Basically, one thing leads to another – bacteria takes away what the body needs, coupled with a Western diet and lack of exercise, which leads to inflammation, leading to affects on the body i.e. diabetes, cancers, etc.

Jeff Leach with the Human Food Project states in his article Anthropology of Microbes, “In chatting with the researchers from Shanghai (about a 26 year old man at 300+ pounds who lost weight with a low-fat, high carb diet and found to have elevated levels of Enterobacter cloacae subsp. or B9), it’s clear that our B29 microbe is not the only heavy-duty endotoxin-producing bacteria that is contributing to obesity and associated metabolic disorders in mice and humans. Several members within the larger Enterobactereriaceae family (within the phylum Proteobacteria) will emerge as opportunistic pathogens as well. Opportunistic in that they only cause significant damage to the host under elevated conditions which are brought on by a western diet and lifestyle (apparently). . . .therefore, ipso facto, elevated levels of Enterobacter cloacae subsp. (B29) in your gut in the presence of a high fat diet maycause an increase in your circulating levels of LPS endotoxins which will in turn increase your levels of inflammation which will definitely contribute to a cascade of metabolic disorders including, but not likely limited to, obesity and type 2 diabetes.” (http://humanfoodproject.com/are-you-carrying-the-obesity-pathogen/)

What are the treatment options?obesity_SS_131375909_081613-617x416

In order to alter the gut for microbiota:

  1. balance of predominant bacteria using the 4R protocol (below)
  2. remove opportunistic bacteria, especially Bacillus sp.
  3. supplement with Bifidobacter sp., and S. boulardii
  4. reduce refined carbohydrates
  5. address all the GI imbalances.

In case you forgot the the 4 R’s to intestinal health, they are:

1. Remove – offending foods, medications, gluten and reduce poor quality fats, carbohydrates, sugars and fermented foods.

2. Replace – what is needed for normal digestion and absorption i.e. betaine HCI, pancreatic enzymes, herbs to aid in digestion (licorice, marshmallow root), fiber and water.

3. Reinoculate – with favorable microbes (probiotics i.e. Lactobacillus sp.) and supplement with prebiotics (i.e. inulin, beta glucan and fiber).

4. Repair – mucosal lining by giving support to healthy intestinal mucosal cells, goblet cells and to the immune system i.e. L-glutamine, zinc, vitamin C.

What are your thoughts concerning obesity and the effect it has on gut health?

Intestinal Health – the Four “R” Program: Part II – Bacteria

bacteria

In Part I of our four-part series, we looked at the gut and how bacteria plays a part in a good way and a bad one. We also presented that there are four steps to creating a healthy gut:  Remove, Replace, Reinoculate, Repair.

In Part II, we’ll look at bacteria specifically in relation to our gut health and what it does to create havoc in our system, not just our gut.

Opportunistic and pathogenic bacteria proliferate in our body, specifically our GI tract, because of our own behavior, namely poor diet; antibiotic use; as well as contaminated animal food sources, water and produce. That being said, it is within reason that the infection can be reversed.

lifecycle_entamoebahistolytica

 

 

http://www.thelifetree.com/amoeba.htm

The symptoms of this invasion present themselves as acute gastritis with abdominal pain, nausea and vomiting, cramping, fever, diarrhea, even influenza-like symptoms are common, including headache and malaise, and sometimes resulting in as bad as bloody diarrhea, colitis and hemolytic uremic syndrome.

As bad as it sounds, there is treatment for bacterial infection: probiotics, prebiotics, vitamins, herbal agents such as goldenseal, citrus seed extract, garlic, oregano oil, and olive leaf extract. At the very least, be sure and rehydrate if you have had any diarrhea.

At Baucom Institute, we deal especially with the gut and treatment of these types of issues. In more invasive cases, we specialize in prescribing medications to deal with the serious nature of these issues.

Do you have any of these symptoms or know anyone who does?

 

Gut Health – Parasites

amoeba05

As we are discussing gut health, what do you consider important to dialogue about in regard to parasites? Regarding Botanical Treatment – what are some of the herbs you would consider using for parasitical infection of the gut? What would you use for Entamoeba Histoliytica? Would you treat people who are asymptomatic and why? What about for pinworms? and Giardia Lamblia?