Autism and Impaired Methylation: PMhx Case – Chris

From the last blog we presented impaired methylation and the connection to autism. This week, we look at a specific case where a subject, named Chris, was given treatment through nutrition and supplements.

  • Treatment: Elimination diet 6 weeks followed by no gluten or cow dairy.autism-baucom-institute

  • EPA/DHA liquid

  • chewable muti-vitamins (organic)

  • Probiotics c FOS

  • B12/5mthf, B6, mg glycinate, Nac

  • Phospho serine at  Hs

The symptoms resolved! Although a few minor issues with dyslexia continued, Chris integrated back into school after his mom took him out of school and home schooled him for a year until she could control his diet.  Methyl-folate and methyl-B12 were added this past year which helps energy and support detoxification in Phase II of the liver function.

nutrition-autism-baucom-instituteINTERVENTION 1: Supplementation with folinic acid and betaine

Although supplementation was effective in normalizing the methionine cycle metabolites to the concentrations in the control subjects, the intervention significantly improved but did not normalize tGSH or GSSG concentrations or tGSH:GSSG

INTERVENTION 2: Supplementation with folinic acid and betaine and Methyl vitamin B12

The addition of injectible methylcobalamin (intervention 2) did not alter the mean concentrations of methionine, SAM, SAH, or homocysteine beyond the alterations induced by the intervention with folinic acid and betaine. However, relative to intervention 1, the addition of injectible methylcobalamin further decreased the concentrations of adenosine and GSSG and further increased the concentrations of methionine, cysteine, and tGSH and SAM:SAH and tGSH:GSSG.

  • http://www.enduracell.com Christine Houghton

    In my opinion, the heavy focus on methylation ignores the ‘upstream’ roles of the oxidative stress/ inflammation duo. Whilst methylation is important, it is just one aspect of the cellular ‘symphony orchestra’. The October PNAS study using a broccoli sprout-based supplement as the sole intervention is testament the fact that observable clinical benefits can occur by addressing the ‘upstream’ factors.
    See the study here: http://www.pnas.org/content/111/43/15550.full.pdf+html

    The most likely reason that this study showed benefit was because the bioactive compound derived from broccoli sprouts, sulforaphane, activates the expression of around 2000 genes coding for enzymes associated with the cells’ own defence system.

    As a nutrigenomically-active plant-derived compound, Sulforaphane protects abnormal cells in the way that Mother Nature herself does. This approach as a foundation does not need knowledge of the gene profile, nor does it require intricate manipulation of methylation pathways using synthetic vitamin supplements.

    Whilst the latter may still be necessary for optimum results, surely this is the 2nd stage of treatment, not the first.